NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Ace your North American Pharmacist Licensure Examination (NAPLEX) with our comprehensive practice test. Features include interactive flashcards, multiple-choice questions, with detailed hints and explanations. Fast-track your pharmacy career today!

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What is a common toxicity associated with 5-FU and MTX?

Constipation
Diarrhea
Xerostomia
Hepatotoxicity

The correct answer is: Diarrhea

Both 5-FU (5-fluorouracil) and MTX (methotrexate) are commonly used chemotherapeutic agents known to cause gastrointestinal toxicity. Specifically, diarrhea is a common adverse effect associated with both drugs. 5-FU can cause mucositis, stomatitis, and diarrhea, while MTX can lead to mucositis, diarrhea, and stomatitis in high doses. Therefore, diarrhea is the correct answer as the common toxicity associated with both 5-FU and MTX. Constipation (Choice A), xerostomia (Choice C), and hepatotoxicity (Choice D) are not typically associated with either 5-FU or MTX use, making them incorrect choices in this context.