NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is a contraindication for using Mannitol in treatment?

  1. High blood pressure

  2. Severe renal disease

  3. Diabetes

  4. Atrial fibrillation

The correct answer is: Severe renal disease

Mannitol is an osmotic diuretic commonly used to reduce intracranial pressure and treat cerebral edema. One of the contraindications for using Mannitol is severe renal disease because Mannitol is excreted unchanged by the kidneys. In the presence of severe renal impairment, Mannitol can accumulate in the body, leading to potential toxicity and worsening renal function. Therefore, it is crucial to avoid Mannitol in patients with severe renal disease to prevent further harm. High blood pressure, diabetes, and atrial fibrillation are not contraindications for using Mannitol specifically.

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