NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is a precaution for the use of Descovy?

Do not use if CrCl<15
Do not use if CrCl<60
Do not use if CrCl<30
No specific precautions

The correct answer is: Do not use if CrCl<30

Descovy is a medication used to treat HIV-1 infection. It is a combination of two drugs, emtricitabine and tenofovir alafenamide, and is only effective in patients with a creatinine clearance (CrCl) of 30 mL/min or greater. Creatinine clearance is a measure of how well the kidneys are functioning and determines how quickly the body can eliminate medications from the blood. Option A and B are incorrect because they indicate that Descovy should not be used if the CrCl is less than 15 or 60, respectively. This is incorrect because the medication can still be safely used as long as the CrCl is above 30. Option D is also incorrect because there are specific precautions that need to be taken when using Descovy, which is to not use it if the CrCl is less than 30. Therefore, option C is the correct answer.