NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is a serious warning associated with Niacin?

  1. Constipation

  2. Rhabdomyolysis

  3. Increased LDL up to 44%

  4. Decreased absorption of vitamin K

The correct answer is: Rhabdomyolysis

One of the serious warnings associated with Niacin is the risk of developing rhabdomyolysis, a serious condition where damaged muscle fibers release toxic substances into the bloodstream. This can lead to kidney failure and other serious complications. Options A, C, and D are not serious warnings associated with Niacin. Constipation is a common side effect that can be managed with proper hydration and dietary changes. Increased LDL levels may occur, but this can be managed by adjusting the dosage of Niacin. Decreased absorption of vitamin K usually does not cause any significant issues and can be addressed by increasing intake of vitamin K-rich foods or taking a supplement. Overall, it is important to closely monitor for symptoms of rhabdomyolysis when taking Niacin and to seek medical attention if any occur.

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