NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is a special precaution when using Mirabegron (Myrbetriq)?

Avoid in patients with diabetes
Use caution with digoxin
Avoid in patients under 18
Use caution with high blood pressure medications

The correct answer is: Use caution with digoxin

When using Mirabegron (Myrbetriq), a beta-3 adrenergic agonist commonly used to treat overactive bladder, it is important to exercise caution when co-administering it with digoxin. Digoxin is a medication commonly used for heart conditions, and when used concomitantly with Mirabegron, there is a risk of increased serum levels of digoxin, leading to potential toxicity. Therefore, it is crucial to monitor patients for signs of digoxin toxicity, such as nausea, vomiting, visual disturbances, and cardiac arrhythmias when these two medications are used together. The other options are not directly related to special precautions when using Mirabegron. Mirabegron does not need to be avoided in patients with diabetes, and there is no specific age restriction for its use (although it is typically used in adults). Additionally, while caution should be exercised when using Mirabegron in patients taking high blood pressure medications due to potential additive effects, the most crucial precaution among the options provided is the need for caution when co-administering Mirabegron with digoxin.