NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is an example of a CYP-2D6 inhibitor?

  1. Hydrocodone

  2. Codeine

  3. Duloxetine

  4. Carvedilol

The correct answer is: Duloxetine

CYP-2D6 inhibitors are a type of medication that inhibit the enzyme CYP-2D6, which is responsible for metabolizing certain drugs in the body. This can lead to increased levels of the drug in the body, potentially causing adverse effects or toxicity. Of the options provided, only Duloxetine is a known CYP-2D6 inhibitor. Hydrocodone, Codeine, and Carvedilol are not CYP-2D6 inhibitors. They may interact with other enzymes or receptors, but they do not specifically inhibit CYP-2D6. Therefore, they are not considered examples of CYP-2D6 inhibitors.

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