NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is indicated for the treatment of Doxorubicin induced toxicity?

  1. Leucovorin

  2. Mesna

  3. Dexrazoxane

  4. Atropine

The correct answer is: Dexrazoxane

Option A Leucovorin is a form of folic acid used to prevent or reduce the side effects of certain medications, such as methotrexate. It is not indicated for the treatment of Doxorubicin induced toxicity. Option B: Mesna is a medication used to prevent or reduce the toxic effects of some chemotherapy drugs. While it may be helpful in reducing toxicity from certain drugs, it is not specifically indicated for Doxorubicin induced toxicity. Option D: Atropine is a medication used to treat certain types of poisoning and to decrease saliva production during surgery. It is not indicated for the treatment of Doxorubicin induced toxicity. The most suitable treatment for Doxorubicin induced toxicity is Dexrazoxane (Option C). Dexrazoxane is a medication used to prevent or reduce the heart damage associated with certain chemotherapy drugs, including Doxorubicin. It works by interfering with the formation of harmful byproducts of Doxorubicin, thus protecting the heart from damage. Therefore, A and B are incorrect as they are not specific treatments for Doxorubicin induced toxicity. D is also incorrect as it is not used for this purpose.