NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is Temsirolimus primarily metabolized by?

  1. CYP2D6

  2. CYP3A4

  3. CYP1A2

  4. MAO

The correct answer is: CYP3A4

Temsirolimus is primarily metabolized by CYP3A4. This enzyme plays a significant role in metabolizing a wide range of drugs including temsirolimus. CYP2D6, CYP1A2, and MAO do not play a major role in the metabolism of temsirolimus.

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