NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is the advised dosage of Apixaban for nonvalvular AF in elderly patients over 80 years?

  1. 5 mg PO BID

  2. 2.5 mg PO BID

  3. 10 mg PO BID

  4. 20 mg QD

The correct answer is: 2.5 mg PO BID

Elderly patients over 80 years of age may have reduced kidney function, which can increase the risk of bleeding with the use of Apixaban. Therefore, the advised dosage for these patients is 2.5 mg PO BID, which is a lower dose compared to the standard 5 mg PO BID for nonvalvular atrial fibrillation. Options A, C, and D are not recommended as they are higher doses and may increase the risk of bleeding in this patient population. Overall, it is important to consider a patient's age and kidney function when determining the appropriate dosage for Apixaban.

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