NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is the first line DMARD for Rheumatoid Arthritis?

  1. Hydroxychloroquine

  2. Sulfasalazine

  3. MTX (Trexall)

  4. Leflunomide

The correct answer is: MTX (Trexall)

Methotrexate (MTX) is considered the first line disease-modifying anti-rheumatic drug (DMARD) for the treatment of Rheumatoid Arthritis. This is because MTX has been extensively studied and has shown to be effective in controlling symptoms of RA and slowing down the progression of joint damage. Hydroxychloroquine, sulfasalazine, and leflunomide are also DMARDs commonly used to treat RA, but they are usually considered second line options after MTX, as they may not be as effective or have more potential side effects. However, the choice of DMARD ultimately depends on the individual case and may vary among patients. It is important to consult with a healthcare professional to determine the best treatment plan for RA.

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