NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is the initial management for mild hypercalcemia of malignancy?

IV hydration with NS and loop diuretics
Administer Rasburicase
Start with high-dose Allopurinol
Immediate dialysis

The correct answer is: IV hydration with NS and loop diuretics

Mild hypercalcemia of malignancy refers to a slightly elevated calcium level in the blood due to cancer. In this case, the initial management aims to bring down the calcium level back to normal range. Option A, IV hydration with NS (normal saline) and loop diuretics, is the recommended initial management as it helps to flush out excess calcium from the body, leading to a decrease in the blood calcium level. Option B, administering Rasburicase, is used in the treatment of tumor lysis syndrome, a different condition that can also cause hypercalcemia. Option C, starting with high-dose Allopurinol, is used for managing gout, which is not related to hypercalcemia. Option D, immediate dialysis, is not recommended for mild hypercalcemia and is reserved for more severe cases.