NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is the main recommendation when switching from Warfarin to Edoxaban?

  1. When INR is < 3

  2. When INR is < 2.5

  3. When INR is < 2

  4. When INR is > 3

The correct answer is: When INR is < 2.5

When transitioning from Warfarin to Edoxaban, the main recommendation is to do so when the patient's INR is less than 2.5. This is because Edoxaban is a direct oral anticoagulant (DOAC) and has a faster onset of action compared to Warfarin. It is safer to switch at a lower INR level to avoid an increased risk of bleeding. Choosing any of the other options would not be the optimal recommendation for this scenario. If the INR is too low (A, C) there is a risk of bleeding or thrombosis, respectively, while if the INR is too high (D) there is a risk of excessive anticoagulation.

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