NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is the mechanism of action of Serolimus (Rapamune)?

  1. mTOR kinase inhibitor; inhibit T-lymphocyte activation/proliferation

  2. Inhibits calcineurin to decrease T-cell activation

  3. Binds to CD80 and CD86 to prevent T-lymphocyte activation

  4. Inhibits DNA replication in rapidly dividing cells

The correct answer is: mTOR kinase inhibitor; inhibit T-lymphocyte activation/proliferation

Serolimus, also known as Rapamune, is a mTOR kinase inhibitor that works by inhibiting the activation and proliferation of T-lymphocytes. This helps to suppress the immune system and prevent rejection of transplanted organs. Option B is incorrect because it refers to another immunosuppressant drug called cyclosporine, which works by inhibiting calcineurin. Option C is incorrect because it refers to another immunosuppressant drug called abatacept, which works by binding to CD80 and CD86 on antigen-presenting cells. Option D is incorrect because it refers to another class of drugs called antimetabolites, which inhibit DNA replication in rapidly dividing cells as a means of fighting cancer.

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