NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is the primary action of Tacrolimus (Prograf) in immunosuppression?

  1. Inhibits purine nucleotide synthesis

  2. Binds to antigens on T-lymphocytes

  3. Suppresses cellular immunity by inhibiting T-lymphocyte activation

  4. Blocks IL-2 receptor on surface of activated T-lymphocytes

The correct answer is: Suppresses cellular immunity by inhibiting T-lymphocyte activation

Tacrolimus (Prograf) primarily acts by suppressing cellular immunity through the inhibition of T-lymphocyte activation. By inhibiting the activation of T-lymphocytes, Tacrolimus helps to prevent the immune system from mounting an aggressive response and thereby reduces the risk of organ rejection in transplant recipients. This mechanism of action distinguishes Tacrolimus from the other options. It does not directly inhibit purine nucleotide synthesis (Choice A), bind to antigens on T-lymphocytes (Choice B), or block the IL-2 receptor on the surface of activated T-lymphocytes (Choice D), making these options incorrect.

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