NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Ace your North American Pharmacist Licensure Examination (NAPLEX) with our comprehensive practice test. Features include interactive flashcards, multiple-choice questions, with detailed hints and explanations. Fast-track your pharmacy career today!

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What is the primary function of DPP-4 inhibitors?

  1. Decrease insulin production

  2. Prevent the breakdown of incretin hormones

  3. Stimulate glucose production

  4. Increase insulin resistance

The correct answer is: Prevent the breakdown of incretin hormones

DPP-4 inhibitors primarily work by preventing the breakdown of incretin hormones. Incretin hormones, such as GLP-1 (glucagon-like peptide 1), play a crucial role in regulating glucose metabolism by stimulating the release of insulin in response to elevated blood glucose levels and inhibiting the release of glucagon, which helps lower blood sugar levels. By inhibiting the enzyme DPP-4 that breaks down these incretin hormones, DPP-4 inhibitors ultimately lead to increased insulin secretion, reduced glucagon release, and improved glucose control in patients with type 2 diabetes.