NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is the primary role of NK1-RA in CINV management?

  1. Treat acute CINV

  2. Prevent anticipatory CINV

  3. Treat delayed CINV

  4. Prevent break through CINV

The correct answer is: Treat delayed CINV

The primary role of NK1 receptor antagonists (NK1-RA) in Chemotherapy-Induced Nausea and Vomiting (CINV) management is to treat delayed CINV. NK1-RA medications are particularly effective in preventing nausea and vomiting that occurs after the first 24 hours post-chemotherapy. They work by blocking the action of substance P, a neurotransmitter involved in the vomiting reflex. While NK1-RA can also help in preventing acute CINV to some extent, their main strength lies in managing delayed CINV. Anticipatory CINV is typically addressed through behavioral therapy or other medications, and breakthrough CINV may require additional doses of antiemetics or other supportive measures.

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