NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is the purpose of HLA and ABO blood group matching in the context of transplantation?

To prevent acute blood loss
To match donor and recipient for blood transfusions
To prevent graft rejection
To determine genetic compatibility

The correct answer is: To prevent graft rejection

HLA (human leukocyte antigen) and ABO blood group matching are crucial in the context of transplantation to prevent graft rejection. HLA matching helps ensure that the recipient's immune system does not recognize the transplanted organ as foreign and reject it. ABO blood group matching is important to prevent antibodies in the recipient's blood from attacking the transplanted organ. Therefore, the purpose of HLA and ABO blood group matching in transplantation is primarily to prevent graft rejection and ensure the success of the transplant.