NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is the target dose for Sacubitril/Valsartan (Entresto)?

  1. 200 mg BID

  2. 100 mg BID

  3. 150 mg BID

  4. 50 mg BID

The correct answer is: 200 mg BID

Sacubitril/valsartan (Entresto) is a combination medication used in the treatment of heart failure with reduced ejection fraction. The target dose for Sacubitril/Valsartan is 200 mg twice daily. This dose has been shown in clinical trials to provide the most benefit in terms of reducing cardiovascular events and improving outcomes in patients with heart failure. Therefore, option A, 200 mg BID, is the correct answer.

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