NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is Tretinoin's (ATRA) primary use in cancer treatment?

  1. First-line for acute myeloid leukemia

  2. First-line in acute promyelocytic leukemia

  3. Second-line therapy for chronic lymphocytic leukemia

  4. First-line for breast cancer

The correct answer is: First-line in acute promyelocytic leukemia

Tretinoin (ATRA)is mainly used in the treatment of acute promyelocytic leukemia (APL). It works by causing the immature cancer cells to mature into normal blood cells. Option A First-line therapy for acute myeloid leukemia (AML) is typically induction chemotherapy, followed by consolidation therapy. Tretinoin is often used as a component of consolidation therapy, but it is not considered first-line for AML. Option C: Chronic lymphocytic leukemia (CLL) is typically treated with a combination of chemotherapy and immunotherapy. Tretinoin is not typically used in the treatment of CLL. Option D: Tretinoin is not commonly used in the treatment of breast cancer. Chemotherapy, hormonal therapy, and targeted therapy are more commonly used to treat breast cancer.