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What is Tretinoin's (ATRA) primary use in cancer treatment?
First-line for acute myeloid leukemia
First-line in acute promyelocytic leukemia
Second-line therapy for chronic lymphocytic leukemia
First-line for breast cancer
The correct answer is: First-line in acute promyelocytic leukemia
Tretinoin (ATRA)is mainly used in the treatment of acute promyelocytic leukemia (APL). It works by causing the immature cancer cells to mature into normal blood cells. Option A First-line therapy for acute myeloid leukemia (AML) is typically induction chemotherapy, followed by consolidation therapy. Tretinoin is often used as a component of consolidation therapy, but it is not considered first-line for AML. Option C: Chronic lymphocytic leukemia (CLL) is typically treated with a combination of chemotherapy and immunotherapy. Tretinoin is not typically used in the treatment of CLL. Option D: Tretinoin is not commonly used in the treatment of breast cancer. Chemotherapy, hormonal therapy, and targeted therapy are more commonly used to treat breast cancer.