NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What major side effect does Raloxifene have?

Increased risk of VTE/death due to stroke
Decreased risk of VTE/death due to stroke
No significant side effects
Increased risk of osteoporosis

The correct answer is: Increased risk of VTE/death due to stroke

Raloxifene is a selective estrogen receptor modulator (SERM) used to prevent and treat osteoporosis in postmenopausal women. One major side effect of Raloxifene is an increased risk of venous thromboembolism (VTE) and death due to stroke. This is because Raloxifene, like estrogen, can increase the risk of blood clots forming in the veins, which may lead to serious complications such as VTE and stroke. It is important to monitor patients on Raloxifene for signs and symptoms of VTE, such as swelling, pain, tenderness, or redness in the leg, and seek medical attention if any of these occur. Options B, C, and D are incorrect: - Option B states that Raloxifene decreases the risk of VTE and death due to stroke, which is inaccurate. - Option C suggests that Raloxifene has no significant side effects, which is incorrect as it is associated with an increased risk of VTE and stroke. - Option D mentions that Raloxifene increases the risk of osteoporosis, which is not true as Raloxifene is actually used to prevent and treat osteoporosis.