NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What needs to be closely monitored when initiating or stopping CYP3A4 inhibitors with Oxycodone?

  1. Blood pressure

  2. Liver function

  3. Serotonin levels

  4. Black Box Warning for respiratory depression

The correct answer is: Black Box Warning for respiratory depression

CYP3A4 inhibitors can increase the effects of Oxycodone, including the risk of respiratory depression. Therefore, when initiating or stopping CYP3A4 inhibitors, it is important to closely monitor for any signs of respiratory depression, such as slow or shallow breathing. This is why it is crucial to follow the black box warning for Oxycodone and regularly assess respiratory status. Monitoring blood pressure, liver function, and serotonin levels are also important, but these are not directly impacted by the use of CYP3A4 inhibitors with Oxycodone.

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