NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What property do hydrophilic antibiotics generally have?

  1. Poor tissue penetration

  2. High lipid solubility

  3. Low renal elimination

  4. Active against mostly intracellular pathogens

The correct answer is: Poor tissue penetration

Hydrophilic antibiotics generally have poor tissue penetration. This is because hydrophilic substances tend to have an affinity for water rather than lipids, making it difficult for them to cross lipid-rich cell membranes and penetrate tissues effectively. As a result, hydrophilic antibiotics may be less effective in reaching their target sites within the body compared to lipophilic antibiotics. This property can impact the overall efficacy of hydrophilic antibiotics in treating infections.

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