NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What should be avoided due to the risk of increasing FQ levels?

  1. Antacids and iron

  2. Probenacid and NSAIDs

  3. Calcium and zinc

  4. MVI and phosphate binders

The correct answer is: Probenacid and NSAIDs

Probenacid and NSAIDs should be avoided due to the risk of increasing FQ levels. Probenacid is a medication used to treat gout and helps to increase the effectiveness of certain antibiotics, including fluoroquinolones (FQs). However, this can also lead to higher levels of FQ in the body, which can increase the risk of side effects and adverse reactions. NSAIDs, or non-steroidal anti-inflammatory drugs, can also increase FQ levels by inhibiting FQ metabolism in the liver. Antacids and iron are not known to increase FQ levels, but they may reduce the absorption of FQs in the body if taken together. Therefore, it is recommended to take FQs at least 2 hours before or 6 hours after taking antacids or iron supplements. Calcium and zinc are not known to interact with FQs and do not increase FQ levels. In fact, calcium and magnesium may help to reduce the potential side effects of fluoroquinolones. MVI, or multi-vitamin supplements, and phosphate binders do not have any known interactions with FQs and do not increase FQ levels. However, it is always important to consult with

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