NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What should be avoided when taking Colchicine for an acute gout attack due to increased myopathy risk?

  1. Pgp or strong CYP3A4 inhibitor

  2. Vitamin C supplements

  3. High-fat meals

  4. Sunlight exposure

The correct answer is: Pgp or strong CYP3A4 inhibitor

Taking Pgp or strong CYP3A4 inhibitors while on Colchicine for an acute gout attack increases the risk of myopathy, a serious and potentially life-threatening muscle disease. This is because these medications can interfere with the breakdown and elimination of Colchicine, leading to higher levels in the body and an increased risk of side effects. Vitamin C supplements, high-fat meals, and sunlight exposure do not have any known interactions with Colchicine and are not associated with an increased risk of myopathy. Therefore, option A is the only incorrect choice and should be avoided while taking Colchicine for an acute gout attack.

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