NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What should be decreased when Substance P/NK1-RAs are used concurrently with dexamethasone due to CYP3A4 inhibition?

NK1-RA dose
5HT-3 RA dose
Dexamethasone dose
Antiemetic combination

The correct answer is: Dexamethasone dose

When using Substance P/NK1-RAs and dexamethasone together, it is important to decrease the dexamethasone dose. This is because CYP3A4 inhibition caused by Substance P/NK1-RAs can increase the levels of dexamethasone in the body, potentially leading to adverse effects. Option A and B are incorrect because they refer to adjusting the doses of the other medications, while C is the correct answer for the medication specifically mentioned in the question. Option D is incorrect because it does not specify which medication within the antiemetic combination should be decreased.