NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

What should be monitored when a loop diuretic is added to digoxin therapy?

1. Blood glucose

2. Electrolytes and renal function

3. Liver enzymes

4. Blood pressure

The correct answer is: Electrolytes and renal function

When a loop diuretic is added to digoxin therapy, it is important to monitor electrolytes and renal function. Loop diuretics can cause an imbalance in electrolytes, such as potassium and magnesium, which can affect the effectiveness of digoxin. Renal function should also be monitored as both digoxin and loop diuretics can have an impact on kidney function. Choice A (Blood glucose) is incorrect because loop diuretics do not directly affect blood glucose levels. Choice C (Liver enzymes) is incorrect because loop diuretics do not affect liver enzymes and digoxin is primarily excreted by the kidneys. Choice D (Blood pressure) is also incorrect because while both loop diuretics and digoxin can affect blood pressure, it is not the top priority when adding a loop diuretic to digoxin therapy. Overall, monitoring electrolytes and renal function is essential for optimizing the effects of digoxin when a loop diuretic is added to therapy.