NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What should be reduced by 50% when taking PDE-5 inhibitors under certain conditions?

The dosage
The frequency of use
The duration of use
The number of different PDE-5 inhibitors used

The correct answer is: The dosage

When taking PDE-5 inhibitors under certain conditions, such as when a patient is also using certain medications like ritonavir, it is recommended to reduce the dosage of the PDE-5 inhibitor by 50%. This reduction helps to avoid potential interactions between the medications and minimize the risk of adverse effects. It is crucial to adjust the dosage to ensure the safety and effectiveness of the treatment. Therefore, reducing the dosage is the correct choice in this scenario. The other options are not directly related to the interactions between PDE-5 inhibitors and certain medications or conditions. Reducing the frequency of use, the duration of use, or the number of different PDE-5 inhibitors used may not address the specific concern of potential drug interactions necessitating a dosage adjustment.