NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What should not be used with paroxetine (Brisdelle) due to interaction concerns?

Aspirin
Warfarin or Tamoxifen
Vitamin C
Calcium supplements

The correct answer is: Warfarin or Tamoxifen

Paroxetine, sold under the brand name Brisdelle, belongs to the class of drugs known as selective serotonin reuptake inhibitors (SSRIs). SSRIs are commonly used to treat depression, anxiety, and other mental health conditions. They work by increasing the levels of a neurotransmitter called serotonin in the brain. However, paroxetine can interact with other medications or substances, causing potentially harmful side effects. Warfarin and Tamoxifen are two medications that should not be used with paroxetine due to possible interactions. Warfarin is a blood thinner commonly used to prevent blood clots, and Tamoxifen is a hormonal therapy used to treat breast cancer. Vitamin C and calcium supplements, although beneficial for overall health, do not interact with paroxetine and can be safely used with this medication. It is important to consult with a healthcare provider before combining any medications, including over-the-counter supplements, with paroxetine to avoid potential interactions.