NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Ace your North American Pharmacist Licensure Examination (NAPLEX) with our comprehensive practice test. Features include interactive flashcards, multiple-choice questions, with detailed hints and explanations. Fast-track your pharmacy career today!

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What significant side effect is attributed to tertiary amine TCAs?

Weight loss
Anticholinergic effects
Increased appetite
Decreased heart rate

The correct answer is: Anticholinergic effects

Tertiary amine tricyclic antidepressants (TCAs) are well-known for their significant anticholinergic side effects. These effects result from the blockage of acetylcholine at muscarinic receptors, leading to symptoms such as dry mouth, blurred vision, constipation, urinary retention, and cognitive impairment. Therefore, option B is the correct answer. Options A, C, and D are incorrect because weight loss is not a typical side effect associated with tertiary amine TCAs; increased appetite is not commonly seen with this medication group; and decreased heart rate is a side effect mainly seen with other drug classes like beta-blockers, rather than tertiary amine TCAs.