NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What significant side effect is associated with Allopurinol (Zyloprim, Aloprim)?

  1. Dizziness

  2. Severe rash

  3. Insomnia

  4. Weight gain

The correct answer is: Severe rash

Allopurinol is commonly associated with a significant side effect of severe rash, known as Stevens-Johnson syndrome or toxic epidermal necrolysis. This potentially life-threatening reaction requires immediate discontinuation of the medication. Monitoring for skin reactions is crucial when a patient is prescribed Allopurinol. Choices A, C, and D are not typically associated with Allopurinol use, making them incorrect in this context.

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