NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What syndrome increases breast cancer risk in men?

  1. Down Syndrome

  2. Turner Syndrome

  3. Klinefelter Syndrome

  4. Marfan Syndrome

The correct answer is: Klinefelter Syndrome

Klinefelter Syndrome is a genetic disorder that results in men having an extra X chromosome, which can increase their risk of developing breast cancer. Down Syndrome (A), Turner Syndrome (B), and Marfan Syndrome (D) do not have an association with an increased risk of breast cancer in men. Down Syndrome is caused by a trisomy of chromosome 21, Turner Syndrome is a missing X chromosome, and Marfan Syndrome is caused by a mutation in the FBN1 gene. These chromosomal abnormalities are not known to have a relationship with breast cancer. Therefore, C is the most accurate and relevant answer.

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