NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What type of antibiotic therapy is suggested for HNPEK coverage?

Beta-lactam/beta-lactamase inhibitor
Aminoglycosides
Tetracyclines
Sulfonamides

The correct answer is: Beta-lactam/beta-lactamase inhibitor

Antibiotic therapy for HNPEK coverage refers to the treatment of infections caused by bacteria that belong to the group of gram-negative organisms known as HNPEK (Haemophilus, Neisseria, Proteus, Escherichia coli, and Klebsiella). The most effective type of antibiotic for this coverage is a beta-lactam/beta-lactamase inhibitor, such as amoxicillin-clavulanate or piperacillin-tazobactam. Aminoglycosides, tetracyclines, and sulfonamides are not as effective for HNPEK coverage as they have limited activity against gram-negative bacteria. Additionally, aminoglycosides and sulfonamides may have more serious side effects and should only be used as alternatives when beta-lactam therapy is not possible. Tetracyclines are only effective against certain types of gram-negative bacteria and are not usually recommended for HNPEK coverage.