NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What type of anticoagulant is recommended for stroke prophylaxis in non-valvular A-Fib?

  1. NOACs

  2. Warfarin

  3. Aspirin

  4. Dipyridamole

The correct answer is: NOACs

For stroke prophylaxis in non-valvular A-Fib (atrial fibrillation), the recommended anticoagulant class is NOACs (Novel Oral Anticoagulants) or DOACs (Direct Oral Anticoagulants) such as apixaban, dabigatran, edoxaban, and rivaroxaban. NOACs are preferred over warfarin due to their similar or better efficacy, more predictable pharmacokinetics, fewer drug interactions, and less need for monitoring compared to warfarin. Aspirin and dipyridamole are not the first-line agents for stroke prophylaxis in A-Fib according to current guidelines.

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