NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What type of inhibitor is Ibalizumab-uiyk (Trogarzo)?

  1. Post-attachment inhibitor

  2. Fusion inhibitor

  3. INSTI based

  4. NNRTI-based

The correct answer is: Post-attachment inhibitor

Ibalizumab-uiyk (Trogarzo) is a monoclonal antibody used in the treatment of HIV/AIDS. It is specifically classified as a post-attachment inhibitor, meaning it prevents the virus from binding to and entering human cells. This mechanism of action makes it different from fusion inhibitors (which prevent the virus from fusing with the cell membrane), INSTI-based drugs (which inhibit the integration of the HIV genome into human DNA), and NNRTI-based drugs (which inhibit viral reverse transcriptase). Therefore, these options are incorrect because they do not accurately describe the mode of action of Ibalizumab-uiyk.

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