NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What warning is associated with Meperidine (Demerol)?

Risk of CNS toxicity in renal impairment/elderly
QT prolongation
Serotonin syndrome
Application site redness

The correct answer is: Risk of CNS toxicity in renal impairment/elderly

While all these choices do have some kind of associated warning, the warning specifically associated with Meperidine is the risk of CNS toxicity in renal impairment/elderly. This is due to the fact that Meperidine is a potent opioid analgesic and its metabolite can accumulate in the body, leading to CNS toxicity in individuals with impaired renal function or in elderly patients. The warning for QT prolongation is associated with other opioids, such as methadone, while serotonin syndrome is more commonly seen with the use of antidepressants. Application site redness is not a commonly reported side effect or warning associated with Meperidine. It is important to always consult with a healthcare professional regarding the risks and warnings of any medication before use.