NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which agent is NOT classified as a topoisomerase I inhibitor?

  1. Irinotecan

  2. Etoposide

  3. Topotecan

  4. Daunorubicin

The correct answer is: Daunorubicin

Topoisomerase I inhibitors are chemotherapy agents that prevent the enzyme topoisomerase I from relieving DNA supercoiling during DNA replication. This results in double-strand breaks in the DNA, ultimately leading to cell death. Option D, Daunorubicin, is NOT classified as a topoisomerase I inhibitor. Daunorubicin belongs to a different class of chemotherapy agents called anthracyclines. Anthracyclines, like Daunorubicin, inhibit topoisomerase II, which is different from the target of topoisomerase I inhibitors. Therefore, the correct answer is Daunorubicin (Option D) as it is not classified as a topoisomerase I inhibitor, unlike the other options listed.

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