NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Ace your North American Pharmacist Licensure Examination (NAPLEX) with our comprehensive practice test. Features include interactive flashcards, multiple-choice questions, with detailed hints and explanations. Fast-track your pharmacy career today!

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Which antibiotic is not appropriate for treating VRE (E. faecium)?

Doxycycline
Quinupristin/Dalfopristin
Daptomycin
Tigecycline

The correct answer is: Doxycycline

Vancomycin-resistant enterococci (VRE), specifically Enterococcus faecium, are known for their resistance to various antibiotics, including vancomycin. Doxycycline (Choice A) is not a suitable option for treating VRE. Doxycycline is a tetracycline antibiotic that is not effective against VRE due to the resistance mechanisms of these bacteria. Quinupristin/Dalfopristin (Choice B), Daptomycin (Choice C), and Tigecycline (Choice D) are all antibiotics that can be considered for treating VRE infections. Quinupristin/Dalfopristin is a streptogramin combination antibiotic, Daptomycin is a cyclic lipopeptide antibiotic, and Tigecycline is a glycylcycline antibiotic. These antibiotics may exhibit effectiveness against VRE strains where other traditional agents like doxycycline fail. Therefore, in the context of treating VRE infections caused specifically by E. faecium, doxycycline is not the appropriate choice, making it the correct answer in this scenario.