NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which antibiotics are known for their risk of seizure?

Quinolones
Carbapenems
Aminoglycosides
Monobactams

The correct answer is: Carbapenems

Carbapenems are known for their risk of seizure due to their potential to lower the seizure threshold. This class of antibiotics can lead to central nervous system side effects, including seizures, particularly in patients with underlying risk factors such as a history of seizures or CNS disorders. It is important for healthcare providers to be cautious when prescribing carbapenems, monitor patients closely for signs of central nervous system toxicity, and consider alternative antibiotics in patients at higher risk for seizures. Among the other options: - Quinolones (Choice A): While quinolones are associated with various side effects such as tendon rupture and central nervous system effects like headache and dizziness, they are not typically known for an increased risk of seizures. - Aminoglycosides (Choice C): Aminoglycosides are more commonly associated with ototoxicity and nephrotoxicity rather than the risk of seizures. - Monobactams (Choice D): While monobactams are generally well tolerated, they are not known for their risk of seizure when compared to carbapenems.