NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

Which antibiotics are known for 1:1 antibiotic IV to oral dosing?

1. Levofloxacin, moxifloxacin

2. Cefazolin, cefuroxime

3. Azithromycin, clarithromycin

4. Amoxicillin, amoxicillin/clavulanate

The correct answer is: Levofloxacin, moxifloxacin

Fluoroquinolones, such as levofloxacin and moxifloxacin, are known for having a 11 ratio for IV and oral dosing. This means that the dosage and efficacy of the antibiotic is the same whether it is administered via IV or taken orally. Other commonly used antibiotics, like cefazolin and cefuroxime, have different dosing recommendations for IV and oral administration. This is because different antibiotics have different bioavailabilities, meaning that their absorption and distribution in the body can vary depending on the route of administration. Therefore, it is important for healthcare providers to carefully consider the appropriate route and dosage for each individual antibiotic. Azithromycin, clarithromycin, and amoxicillin are not known for having a 1:1 ratio for IV to oral dosing.