NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

Disable ads (and more) with a membership for a one time $4.99 payment

Ace your North American Pharmacist Licensure Examination (NAPLEX) with our comprehensive practice test. Features include interactive flashcards, multiple-choice questions, with detailed hints and explanations. Fast-track your pharmacy career today!

Start Multiple Choice Practice Test
Start Flash Cards

Practice this question and more.

Which chemotherapy agents are known to work independently of the cell cycle phase?

  1. Topoisomerase I inhibitors

  2. Antimetabolites

  3. Alkylating agents

  4. GnRH antagonists

The correct answer is: Alkylating agents

Alkylating agents are known to work independently of the cell cycle phase. This is because alkylating agents act by forming covalent bonds with DNA, leading to cross-linking between DNA strands and preventing cell replication. As a result, alkylating agents are effective not only on cells that are actively dividing (in specific cell cycle phases) but also on cells that are resting or not actively dividing. On the other hand: - Topoisomerase I inhibitors (option A) work in the S phase of the cell cycle. - Antimetabolites (option B) disrupt specific phases of the cell cycle, primarily the S phase. - GnRH antagonists (option D) work by blocking the production of certain hormones but are not directly related to interfering with the cell cycle.

More Questions Like This