NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which class of drugs is known for increasing the QT interval and poses the highest risk?

  1. Antidepressants

  2. Antiemetics

  3. Antipsychotics

  4. Anti-infectives

The correct answer is: Antipsychotics

Antipsychotics are known for increasing the QT interval and pose the highest risk among the classes of drugs listed. Antipsychotics can prolong the QT interval, which can lead to a life-threatening arrhythmia known as Torsades de Pointes. It is important for healthcare providers to monitor patients who are taking antipsychotic medications for any signs or symptoms of QT prolongation to prevent serious cardiac events. Antidepressants, antiemetics, and anti-infectives do have the potential for causing QT prolongation as well, but antipsychotics are generally associated with a higher risk compared to these other drug classes. It is crucial for healthcare providers to be aware of the potential for QT interval prolongation with these medications and take appropriate precautions when prescribing them to patients.

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