NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which classes of drugs are associated with the risk of ototoxicity?

  1. Aminoglycosides, cisplatin, loops, salicylates, vancomycin

  2. Beta-blockers, ACE inhibitors, ARBs, calcium channel blockers

  3. NSAIDs, COX-2 inhibitors, acetaminophen, aspirin

  4. Thiazides, potassium-sparing diuretics, carbonic anhydrase inhibitors

The correct answer is: Aminoglycosides, cisplatin, loops, salicylates, vancomycin

Ototoxicity is a condition where medications can cause damage to the inner ear and result in hearing loss, tinnitus, or balance problems. The drugs associated with this risk are aminoglycosides, cisplatin, loops, salicylates, and vancomycin. These drugs have been shown to have the potential to cause damage in the inner ear and should be used with caution in patients who may be at a higher risk for ototoxicity, such as those with pre-existing inner ear disorders. The other options (B, C, D) do not have a known association with ototoxicity and are not commonly associated with hearing loss or inner ear damage. Therefore, they are incorrect answers.

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