NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which combination is considered first line for acute otitis media (recurrence)?

  1. Penicillin VK and Amoxicillin

  2. Amoxicillin and Clavulanate

  3. Dicloxacillin and Oxacillin

  4. Penicillin and Tazobactam

The correct answer is: Amoxicillin and Clavulanate

Amoxicillin and Clavulanate is considered first line for acute otitis media (recurrence) because it provides broad spectrum coverage against the most common causative bacteria, including Streptococcus pneumoniae and Haemophilus influenzae. Penicillin VK and Amoxicillin are also commonly used for acute otitis media, but they do not cover as many bacterial species as Amoxicillin and Clavulanate. Dicloxacillin and Oxacillin are not typically recommended for acute otitis media because they are more commonly used to treat skin and soft tissue infections. Penicillin and Tazobactam is not a common first line treatment for acute otitis media because Tazobactam is more potent against Gram-negative bacteria and may not provide adequate coverage for the causative bacteria in acute otitis media.

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