NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which compound is a SSRI and 5-HT1A partial agonist?

  1. Vortioxetine

  2. Bupropion

  3. Vilazodone

  4. Desvenlafaxine

The correct answer is: Vilazodone

Vortioxetine, Bupropion, and Desvenlafaxine are all antidepressants that differ from vilazodone in their mechanisms of action. While vilazodone is a SSRI and 5-HT1A partial agonist, vortioxetine is a serotonin modulator and stimulator, bupropion is a norepinephrine and dopamine reuptake inhibitor, and desvenlafaxine is a serotonin-norepinephrine reuptake inhibitor. It is important to note these differences when choosing the appropriate antidepressant for a patient.

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