NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which CV drug requires dose adjustment in CKD patients?

Atenolol
Rivaroxaban
Losartan
Nifedipine

The correct answer is: Rivaroxaban

Rivaroxaban is the correct answer because it is a direct oral anticoagulant (DOAC) that requires dose adjustment in patients with Chronic Kidney Disease (CKD). This is because patients with CKD have a reduced ability to eliminate the drug from their body, leading to a higher risk of bleeding if the dose is not adjusted. Atenolol is a beta-blocker used for hypertension and does not require any dose adjustments in CKD patients. Losartan is an angiotensin receptor blocker that is not affected by CKD and therefore does not require dose adjustments. Nifedipine is a calcium channel blocker that also does not require dose adjustments in CKD patients. While all these drugs may be used for conditions related to CKD, only Rivaroxaban requires a specific dose adjustment in this patient population.