NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Ace your North American Pharmacist Licensure Examination (NAPLEX) with our comprehensive practice test. Features include interactive flashcards, multiple-choice questions, with detailed hints and explanations. Fast-track your pharmacy career today!

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Which drug combination is contraindicated in pregnancy due to teratogenic risk?

Metformin/pioglitazone
Phentermine/topiramate ER
Insulin/liraglutide
Sulfonylureas/thiazolidinediones

The correct answer is: Phentermine/topiramate ER

Phentermine/topiramate ER is contraindicated in pregnancy due to teratogenic risk. Phentermine is classified as FDA pregnancy category X, indicating that there is evidence of fetal risk based on human data, while topiramate is classified as pregnancy category D, indicating positive evidence of human fetal risk based on adverse reaction data. Therefore, the combination of phentermine/topiramate ER poses a significant risk of birth defects and should be avoided in pregnant women or women planning to become pregnant. The other drug combinations listed do not have the same level of teratogenic risk as phentermine/topiramate ER.