NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which drug group does not require refrigeration?

  1. Lorazepam (continuous infusions)

  2. Metronidazole

  3. Taxanes

  4. Lipids (1.2 micron)

The correct answer is: Metronidazole

As an antimicrobial, Metronidazole does not require refrigeration as it does not contain proteins that could be denatured by temperature changes. Lorazepam, lipids, and Taxanes all need to be refrigerated in order to maintain their efficacy and prevent degradation. Lorazepam is a benzodiazepine, which is a class of drugs known for their sedative and anxiolytic properties. Lipids are essential for various bodily functions and are often added to parenteral nutrition solutions. Taxanes are a class of chemotherapy drugs used to treat cancer. Unlike Metronidazole, these drugs contain proteins that are sensitive to temperature changes, making refrigeration necessary to maintain their stability and potency.

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