NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which drug interactions decrease hormonal contraception efficacy?

  1. NSAIDs

  2. Vitamin C supplements

  3. Antibiotics like rifampin and anticonvulsants

  4. Beta-blockers

The correct answer is: Antibiotics like rifampin and anticonvulsants

Antibiotics like rifampin and anticonvulsants are known to decrease the efficacy of hormonal contraception. This is because these medications can induce hepatic enzymes, specifically cytochrome P450 enzymes, which can lead to increased metabolism and decreased effectiveness of hormonal contraceptives. It is important for healthcare providers to be aware of this drug interaction to provide appropriate counseling to patients using hormonal contraception while taking these medications.

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