NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which drug is a CYP-3A4 Inducer?

  1. Ritonavir

  2. Rifampin

  3. Diltiazem

  4. Ketoconazole

The correct answer is: Rifampin

Rifampin is the correct answer because it is known to be a cytochrome P450 3A4 inducer. CYP3A4 is a major enzyme responsible for the metabolism of many drugs. By inducing CYP3A4, rifampin can increase the metabolism of drugs metabolized by this enzyme, leading to lower plasma concentrations and potentially reduced efficacy of co-administered drugs. Options A, C, and D are not CYP-3A4 inducers. Ritonavir is actually a CYP3A4 inhibitor, Diltiazem is a CYP3A4 inhibitor, and Ketoconazole is also a CYP3A4 inhibitor.

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