NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which drug is NOT listed with a boxed warning for liver damage?

  1. Amiodarone

  2. Acetaminophen

  3. Caffeine

  4. Isoniazid

The correct answer is: Caffeine

Caffeine is NOT listed with a boxed warning for liver damage. While excessive caffeine consumption can potentially lead to adverse effects like increased heart rate, restlessness, and insomnia, it is not associated with causing liver damage severe enough to warrant a boxed warning. On the other hand: - Amiodarone is associated with hepatotoxicity and can cause liver damage. - Acetaminophen is known for its potential to cause severe liver damage, especially in cases of overdose. - Isoniazid is another medication that can cause liver damage, particularly in patients who are slow acetylators. Therefore, among the given options, Caffeine is the correct choice as it is NOT listed with a boxed warning for liver damage.